Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes.

  title={Hepatocarcinogenesis by diethylnitrosamine in rats fed high dietary levels of lipotropes.},
  author={L. Poirier},
  journal={Journal of the National Cancer Institute},
  volume={54 1},
  • L. Poirier
  • Published 1975
  • Medicine
  • Journal of the National Cancer Institute
  • The effects of high dietary levels of lipotropes on the carcinogenic activity of diethylnitrosamine (DENA) in rats were studied. All animals given DENA, with or without a dietary supplement, developed hepatocellular carcinomas. The mean survival times of all groups of rats dying with hepatocellular carcinomas after DENA treatment were determined. Choline, betaine, and folic acid consistently exerted no significant effect on those mean survival times. In rats receiving approximately equal to 2… CONTINUE READING
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