Hepatobiliary excretion of berberine.

@article{Tsai2004HepatobiliaryEO,
  title={Hepatobiliary excretion of berberine.},
  author={Pi-Lo Tsai and Tung-Hu Tsai},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2004},
  volume={32 4},
  pages={
          405-12
        }
}
Berberine is a bioactive herbal ingredient isolated from the roots and bark of Berberis aristata or Coptis chinensis. To investigate the detailed pharmacokinetics of berberine and its mechanisms of hepatobiliary excretion, an in vivo microdialysis coupled with high-performance liquid chromatography was performed. In the control group, rats received berberine alone; in the drug-treated group, 10 min before berberine administration, the rats were injected with cyclosporin A (CsA), a P… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 58 CITATIONS, ESTIMATED 40% COVERAGE

Extensive intestinal first-pass elimination and predominant hepatic distribution of berberine explain its low plasma levels in rats.

  • Drug metabolism and disposition: the biological fate of chemicals
  • 2010
VIEW 10 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Effect of ion-pair formation with bile salts on the in vitro cellular transport of berberine

  • Archives of pharmacal research
  • 2008
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Emerging Fixed-Dose Combination Treatments for Hyperlipidemia

  • Journal of cardiovascular pharmacology and therapeutics
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND

FILTER CITATIONS BY YEAR

2005
2019

CITATION STATISTICS

  • 6 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Determination of berberine in plasma, urine and bile by high-performance liquid chromatography.

  • Journal of chromatography. B, Biomedical applications
  • 1995
VIEW 2 EXCERPTS
HIGHLY INFLUENTIAL

Acute effects of different immunosuppressive drugs on pancreatic, islet, renal, and arterial hepatic blood flow in anesthetized rats

  • Transplant international : official journal of the European Society for Organ Transplantation
  • 1994
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL