Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL.

  title={Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL.},
  author={Albert K. Groen and Vincent W. Bloks and Robert Hj Bandsma and Roelof Ottenhoff and Giovanna Chimini and Folkert Kuipers},
  journal={The Journal of clinical investigation},
  volume={108 6},
The ABC transporter ABCA1 regulates HDL levels and is considered to control the first step of reverse cholesterol transport from the periphery to the liver. To test this concept, we studied the effect of ABCA1 deficiency on hepatic metabolism and hepatobiliary flux of cholesterol in mice. Hepatic lipid contents and biliary secretion rates were determined in Abca1(-/-), Abca1(+/-), and Abca1(+/+) mice with a DBA background that were fed either standard chow or a high-fat, high-cholesterol diet… CONTINUE READING


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