Hepatobiliary Manifestations of Sickle Cell Anemia

  title={Hepatobiliary Manifestations of Sickle Cell Anemia},
  author={Hussain Issa and Ahmed Hassan Al-Salem},
  booktitle={Gastroenterology research},
Sickle cell anemia is one of the common hemoglobinopathies around the world. It results from a single change of one amino acid valine instead of glutamic acid in the hemoglobin beta change. This change leads to polymerization of the hemoglobin when the oxygen saturation is lowered, resulting in deformity of the red blood cells and microvascular occlusion. Sickle cell anemia can affect any part of the body and one of the main organs to be affected is the hepatobiliary system either directly from… CONTINUE READING