HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology

  title={HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology},
  author={Christoph Gille and Christian B{\"o}lling and Andreas Hoppe and Sascha Bulik and Sabrina Hoffmann and Katrin H{\"u}bner and Anja Karlst{\"a}dt and Ram Ganeshan and Matthias K{\"o}nig and Kristian Rother and Michael Weidlich and J{\"o}rn Behre and H G Holzh{\"u}tter},
  journal={Molecular Systems Biology},
  pages={411 - 411}
We present HepatoNet1, the first reconstruction of a comprehensive metabolic network of the human hepatocyte that is shown to accomplish a large canon of known metabolic liver functions. The network comprises 777 metabolites in six intracellular and two extracellular compartments and 2539 reactions, including 1466 transport reactions. It is based on the manual evaluation of >1500 original scientific research publications to warrant a high‐quality evidence‐based model. The final network is the… 
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