Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways.

@article{Wang2015HepatoprotectiveEO,
  title={Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways.},
  author={Ying Wang and Yiming Jiang and Xiaomei Fan and Huasen Tan and Hang Zeng and Yongtao Wang and Pan Chen and Min Huang and Huichang Bi},
  journal={Toxicology letters},
  year={2015},
  volume={236 2},
  pages={82-9}
}
Resveratrol (RES) has been shown to possess many pharmacological activities including protective effect against liver damage induced by hepatotoxins. In the present study, the hepato-protective effect of RES against acetaminophen (APAP)-induced liver injury in mice and the involved mechanisms was investigated. This study clearly demonstrated that administration of RES three days before APAP treatment significantly alleviated APAP-induced hepatotoxicity, as evidenced by morphological… CONTINUE READING