Hepatitis E virus and neurological manifestations

  title={Hepatitis E virus and neurological manifestations},
  author={Yunlong Li and Maikel Petrus Peppelenbosch},
  journal={Journal of the Neurological Sciences},



Evidence for Independent Hepatitis E Virus Replication in the Brain

A 46-year-old man presented with a 5-year history of fatigue, frequent painful muscular spasms in the extremities, and tingling sensations in the hands and feet. His medical history consisted of

Screening of hepatitis E in patients presenting for acute neurological disorders.

Hepatitis E: an underestimated emerging threat

Improvements are required in terms of recognition and diagnosis of HEV infection if the authors are to understand the natural history of the disease, improve management and reduce the burden of disease around the world.

Hepatitis E Virus and Guillain-Barré Syndrome.

A century ago when Guillain, Barré, and Strohl described the acute inflammatory polyneuropathic syndrome (GuillainBarré syndrome [GBS]) for which they are still eponymously remembered, they noted

Extrahepatic manifestations of hepatitis E virus

All published reports describing hepatitis E virus–associated extrahepatic manifestations are reviewed, including membranoproliferative glomerulonephritis with or without cryoglobulinemia and membranousglomerul onephritis.

Evidence of Hepatitis E virus breaking through the blood–brain barrier and replicating in the central nervous system

Results provide strong evidence that HEV is able to damage the blood–brain barrier (BBB), replicate in brain and spinal cord, and hammer the causative role of HEV in the pathogenesis of neurologic disorders.

Neuralgic amyotrophy and hepatitis E virus infection

Investigation of the role of HEV in NA in other geographical locations and to determine pathophysiologic mechanisms finds acute hepatitis E is found in 10% of patients with NA from the United Kingdom and the Netherlands.