Hepatitis E virus and neurological injury

@article{Dalton2016HepatitisEV,
  title={Hepatitis E virus and neurological injury},
  author={H. Dalton and N. Kamar and J. V. Eijk and B. Mclean and P. Cintas and R. Bendall and B. Jacobs},
  journal={Nature Reviews Neurology},
  year={2016},
  volume={12},
  pages={77-85}
}
Hepatitis E is hyperendemic in many developing countries in Asia and Africa, and is caused by hepatitis E virus (HEV) genotypes 1 and 2, which are spread via the faecal–oral route by contaminated water. Recent data show that HEV infection is also endemic in developed countries. In such geographical settings, hepatitis E is caused by HEV genotypes 3 and 4, and is mainly a porcine zoonosis. In a minority of cases, HEV causes acute and chronic hepatitis, but infection is commonly asymptomatic or… Expand
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References

SHOWING 1-10 OF 139 REFERENCES
Hepatitis E Virus and Neurologic Disorders
TLDR
During 2004-2009, among 126 patients with locally acquired acute and chronic HEV genotype 3 infection, neurologic complications developed in 7: inflammatory polyradiculopathy, Guillain-Barre syndrome, bilateral brachial neuritis, encephalitis, and ataxia/proximal myopathy. Expand
Hepatitis E virus-induced severe myositis.
TLDR
A first case of Guillain–Barré syndrome associated with severe necrotizing myositis occurred in a liver-transplant patient in acute HEV-infection phase, who then recovered after ribavirin therapy. Expand
Hepatitis E-associated encephalopathy in a renal transplant recipient
TLDR
Serological screening should be added to standard pretransplant virological screening, so that patients without antibodies could be vaccinated and more widespread knowledge about this virus and its extrahepatic manifestations may lead to a quicker diagnosis, and may limit pathology. Expand
Hepatitis E-associated Parsonage-Turner syndrome, France.
TLDR
It is described here an unusual case of hepatitis E consisting in a Parsonage-Turner syndrome (also known as neuralgic amyotrophy), for which diagnosis was retrospective and is to the authors' knowledge the sixth report of a P Carsonnage Turner syndrome associated with HEV. Expand
Hepatitis E – an unexpected problem at home
TLDR
It is important to consider hepatitis E when investigating patients with liver injury, who may otherwise be diagnosed as drug-related or seronegative hepatitis, after finding a 56-year-old Caucasian who presented with acute upper limb pain andweakness to have neurological manifestations of hepatitis E. Expand
Hepatitis E: an emerging infection in developed countries.
TLDR
Patients with unexplained hepatitis should be tested for hepatitis E, whatever their age or travel history, and the source and route of infection remain uncertain, but it might be a porcine zoonosis. Expand
Hepatitis E Virus‐Induced Neurological Symptoms in a Kidney‐Transplant Patient with Chronic Hepatitis
  • N. Kamar, J. Izopet, +4 authors L. Rostaing
  • Medicine
  • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
  • 2010
TLDR
A case where neurological symptoms, that is peripheral nerve involvement with proximal muscular weakness that affected the four limbs joints with central nervous‐system involvement and bilateral pyramidal syndrome, occurred in a kidney‐transplant patient who was chronically infected by HEV is reported. Expand
Myasthenia Gravis Associated with Acute Hepatitis E Infection in Immunocompetent Woman
TLDR
A case of HEV infection in an immunocompetent woman who had muscle-specific kinase (MuSK) antibody–positive myasthenia gravis associated with HEV replication is reported. Expand
Association between hepatitis E and neurological disorders: two case studies and literature review.
  • A. Deroux, J. Brion, +6 authors P. Pavèse
  • Medicine
  • Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2014
TLDR
Two cases of HEV with neurological symptoms are discussed, one with encephalitis, and the other with Parsonage Turner syndrome, which appeared concomitantly with liver cytolysis and disappeared quickly, following the viral kinetics. Expand
Hepatitis E and neuralgic amyotrophy: Five cases and review of literature.
  • A. Dartevel, B. Colombe, +5 authors L. Bouillet
  • Medicine
  • Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
  • 2015
TLDR
In industrialized countries, any neuralgic amyotrophy, particularly if there is bilateral, asymmetric associated with involvement of nerves outside the brachial plexus, should lead physicians to consider a diagnosis of acute hepatitis E. Expand
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