Hepatitis C virus virology and new treatment targets

@article{Meier2009HepatitisCV,
  title={Hepatitis C virus virology and new treatment targets},
  author={Volker Meier and Giuliano Ramadori},
  journal={Expert Review of Anti-infective Therapy},
  year={2009},
  volume={7},
  pages={329 - 350}
}
  • V. Meier, G. Ramadori
  • Published 1 April 2009
  • Medicine, Biology
  • Expert Review of Anti-infective Therapy
Hepatitis C virus (HCV) infection is the leading cause of chronic liver disease. An estimated 130 million people worldwide are persistently infected with HCV. Almost half of patients who have chronic HCV infection cannot be cured with the standard treatment consisting of pegylated IFN-α and ribavirin. For those patients who do not respond to this standard antiviral therapy, there is currently no approved treatment option available. Recent progress in structure determination of HCV proteins and… 
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References

SHOWING 1-10 OF 259 REFERENCES
The Scientific Challenge of Hepatitis C
TLDR
Although to date no one has been able to grow HCV reliably in a laboratory culture of cells, on page 110, researchers describe a new system for culturing HCV9s RNA.
Replication of hepatitis C virus.
TLDR
This review summarizes the current knowledge about HCV replication and describes attempts pursued in the last few years to establish efficient and reliable cell culture systems.
Immunology of hepatitis C virus infection
TLDR
Recent studies in humans and chimpanzees have significantly enhanced understanding of the interaction between HCV and the host’s immune system, and the possible mechanisms of how HCV establishes chronic infection are discussed.
Binding of hepatitis C virus to CD81.
TLDR
Recombinant molecules containing this loop bound HCV and antibodies that neutralize HCV infection in vivo inhibited virus binding to CD81 in vitro.
Hepatitis C virus entry: Molecular biology and clinical implications
TLDR
The impact of recently identified viral and host cell factors for HCV attachment and entry is summarized and clinical implications of this important process for the pathogenesis of HCV infection and novel therapeutic interventions are discussed.
Antiviral therapy for chronic hepatitis C: past, present, and future
TLDR
Antiviral therapy for chronic hepatitis C has dramatically advanced since the discovery of the hepatitis C virus (HCV) in 1989 and the introduction of interferon (IFN) monotherapy in the early 1990s, with new types of anti-HCV agents needed for those patients that do not respond to combination therapy.
Chemical genetics approach to hepatitis C virus replication: cyclophilin as a target for anti‐hepatitis C virus strategy
TLDR
Using a cell culture‐based screening, chemical genetics analysis identified CyPB as a cellular cofactor of HCV genome replication and a target for novel anti‐HCV agents.
Complete Replication of Hepatitis C Virus in Cell Culture
TLDR
A full-length HCV genome that replicates and produces virus particles that are infectious in cell culture (HCVcc) is described, suggesting that this in vitro system will aid in the search for improved antiviral compounds.
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3
4
5
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