Hepatitis C virus subverts liver-specific miR-122 to protect the viral genome from exoribonuclease Xrn2.


The abundant, liver-specific microRNA miR-122 forms extensive base-pairing interactions with the 5' noncoding region of the hepatitis C virus (HCV) RNA genome, protecting the viral RNA from degradation. We discovered that the 5'-3' exoribonuclease Xrn2, which plays a crucial role in the transcription termination of RNA polymerase II, modulates HCV RNA… (More)
DOI: 10.1016/j.chom.2014.07.006


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