Hepatitis C virus replicons: potential role for drug development

@article{Bartenschlager2002HepatitisCV,
  title={Hepatitis C virus replicons: potential role for drug development},
  author={Ralf Bartenschlager},
  journal={Nature Reviews Drug Discovery},
  year={2002},
  volume={1},
  pages={911-916}
}
The development of causal therapies depends on the availability of systems to determine the inhibitory capacity of a compound. As viruses are obligate intracellular parasites, the efficacy of an antiviral drug is usually evaluated in a cell-culture system. Unfortunately, the hepatitis C virus, the principal causative agent of acute and chronic liver disease, cannot be propagated efficiently in the laboratory. However, the recent development of a replicon system opens up an encouraging… CONTINUE READING

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