Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells.

@article{SchulzeKrebs2005HepatitisCV,
  title={Hepatitis C virus-replicating hepatocytes induce fibrogenic activation of hepatic stellate cells.},
  author={Anja Schulze-Krebs and Dorothee Preimel and Yury V Popov and Ralf Bartenschlager and Volker Lohmann and Massimo Pinzani and Detlef B Schuppan},
  journal={Gastroenterology},
  year={2005},
  volume={129 1},
  pages={246-58}
}
BACKGROUND & AIMS The mechanism by which hepatitis C virus induces liver fibrosis remains largely obscure. To characterize the profibrogenic potential of hepatitis C virus, we used the hepatitis C virus replicon cell line Huh-7 5-15, which stably expresses the nonstructural hepatitis C virus genes NS3 through NS5B, and hepatic stellate cells as fibrogenic… CONTINUE READING