Hepatitis C virus particles of different density in the blood of chronically infected immunocompetent and immunodeficient patients: Implications for virus clearance by antibody.

@article{Pumeechockchai2002HepatitisCV,
  title={Hepatitis C virus particles of different density in the blood of chronically infected immunocompetent and immunodeficient patients: Implications for virus clearance by antibody.},
  author={Wanna Pumeechockchai and Debra J. Bevitt and Kaushik Agarwal and Theoni Petropoulou and Berit Langer and Bernd H. Belohradsky and Margaret Fiona Bassendine and Geoffrey L. Toms},
  journal={Journal of medical virology},
  year={2002},
  volume={68 3},
  pages={335-42}
}
The purpose of this study was to analyse the influence of the humoral immune response on the generation and clearance of hepatitis C virus (HCV) RNA containing particles in the blood of chronically infected patients. Blood samples were fractionated by sequential flotation ultracentrifugation and HCV RNA was recovered in three fractions: low density of < 1.063 g/ml, intermediate density of 1.063-1.21 g/ml, and high density of > 1.21 g/ml. Serum low-density lipoproteins co-fractionated with the… CONTINUE READING