Hepatitis C virus lymphotropism: lessons from a decade of studies.

  title={Hepatitis C virus lymphotropism: lessons from a decade of studies.},
  author={Anna Linda Zignego and Carlo Giannini and Monica Monti and L Gragnani},
  journal={Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver},
  volume={39 Suppl 1},
The possibility that HCV infects lymphoid cells has been widely discussed. Evidence in favor of HCV tropism for lymphoid cells derives from a series of data including: (1) the higher sensitivity of testing HCVRNA in PBMC than in serum or plasma samples, with possible detection of HCV RNA-positive PBMC in the absence of HCV viremia; (2) short-term cultures of PBMC which yield a significant increase in the amount of viral RNA on stimulation by mitogens; (3) results of "in situ" methods (i.e. in… CONTINUE READING


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