Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes.

@article{Machida2010HepatitisCV,
  title={Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes.},
  author={Keigo Machida and George McNamara and Kevin T-H Cheng and Jeffrey R. Huang and Chun-Hsiang Wang and Lucio Comai and Jing-Hsiung James Ou and Michael M C Lai},
  journal={Journal of immunology},
  year={2010},
  volume={185 11},
  pages={6985-98}
}
Hepatitis C virus (HCV) infection is associated with the development of hepatocellular carcinoma and putatively also non-Hodgkin's B cell lymphoma. In this study, we demonstrated that PBMCs obtained from HCV-infected patients showed frequent chromosomal aberrations and that HCV infection of B cells in vitro induced enhanced chromosomal breaks and sister chromatid exchanges. HCV infection hypersensitized cells to ionizing radiation and bleomycin and inhibited nonhomologous end-joining repair… CONTINUE READING

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