Hepatitis C virus infection impairs IRF-7 translocation and Alpha interferon synthesis in immortalized human hepatocytes.

@article{Raychoudhuri2010HepatitisCV,
  title={Hepatitis C virus infection impairs IRF-7 translocation and Alpha interferon synthesis in immortalized human hepatocytes.},
  author={Amit Raychoudhuri and Shubham Shrivastava and Robert David Steele and Srikanta Dash and Tatsuo Kanda and Ranjit Ray and Ratna B Ray},
  journal={Journal of virology},
  year={2010},
  volume={84 21},
  pages={10991-8}
}
Hepatitis C virus (HCV) establishes chronic infection in a significant number of infected humans, although the mechanisms for chronicity remain largely unknown. We have previously shown that HCV infection in immortalized human hepatocytes (IHH) induces beta interferon (IFN-β) expression (T. Kanda, R. Steele, R. Ray, and R. B. Ray, J. Virol. 81:12375-12381, 2007). However, the regulation of the downstream signaling pathway for IFN-α production by HCV is not clearly understood. In this study, the… CONTINUE READING
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