Hepatitis C virus infection enhances TNFα-induced cell death via suppression of NF-κB.

@article{Park2012HepatitisCV,
  title={Hepatitis C virus infection enhances TNFα-induced cell death via suppression of NF-κB.},
  author={Junseong Park and Wonseok Kang and Seung-wook Ryu and Woo-Il Kim and Dong-Yeop Chang and Dong Ho Lee and Do Youn Park and Y Choi and KyungSun Choi and Eui-Cheol Shin and Chulhee Choi},
  journal={Hepatology},
  year={2012},
  volume={56 3},
  pages={831-40}
}
UNLABELLED Hepatitis C virus (HCV) infection results in liver injury and long-term complications, such as liver cirrhosis and hepatocellular carcinoma. Liver injury in HCV infection is believed to be caused by host immune responses, not by viral cytopathic effects. Tumor necrosis factor-alpha (TNF-α) plays a pivotal role in the inflammatory processes of hepatitis C. TNF-α induces cell death that can be ameliorated by nuclear factor kappaB (NF-κB) activation. We investigated the regulation of… CONTINUE READING
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