Hepatitis C virus infection alters P-body composition but is independent of P-body granules.

@article{PrezVilar2012HepatitisCV,
  title={Hepatitis C virus infection alters P-body composition but is independent of P-body granules.},
  author={Gemma P{\'e}rez-Vilar{\'o} and Nicoletta Scheller and Ver{\'o}nica Saludes and Juana D{\'i}ez},
  journal={Journal of virology},
  year={2012},
  volume={86 16},
  pages={8740-9}
}
Processing bodies (P-bodies) are highly dynamic cytoplasmic granules conserved among eukaryotes. They are present under normal growth conditions and contain translationally repressed mRNAs together with proteins from the mRNA decay and microRNA (miRNA) machineries. We have previously shown that the core P-body components PatL1, LSm1, and DDX6 (Rck/p54) are required for hepatitis C virus (HCV) RNA replication; however, how HCV infection affects P-body granules and whether P-body granules per se… CONTINUE READING