Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway.

@article{JackelCram2010HepatitisCV,
  title={Hepatitis C virus genotype-3a core protein enhances sterol regulatory element-binding protein-1 activity through the phosphoinositide 3-kinase-Akt-2 pathway.},
  author={Candice Jackel-Cram and Ling Qiao and Zhongua Xiang and Robert Brownlie and Yan Zhou and Lorne Babiuk and Qiang Liu},
  journal={The Journal of general virology},
  year={2010},
  volume={91 Pt 6},
  pages={1388-95}
}
Hepatitis C virus genotype-3a (HCV-3a) is directly linked to the development of steatosis. We previously showed that, through sterol regulatory element binding protein-1 (SREBP-1), HCV-3a core protein upregulates the promoter activity of fatty acid synthase, a major enzyme involved in de novo lipid synthesis. In this study, we investigated whether HCV-3a core can activate SREBP-1 and studied the role of phosphoinositide 3-kinase (PI3K)-Akt-2 pathway in modulating SREBP-1 activity by HCV-3a core… CONTINUE READING

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