Hepatitis C virus genome complexity correlates with response to interferon therapy: a study in French patients with chronic hepatitis C.

@article{Guen1997HepatitisCV,
  title={Hepatitis C virus genome complexity correlates with response to interferon therapy: a study in French patients with chronic hepatitis C.},
  author={B Le Guen and Giovanni Squadrito and Bertrand Nalpas and P. Guerre Berthelot and Stanislas Pol and Christian Br{\'e}chot},
  journal={Hepatology},
  year={1997},
  volume={25 5},
  pages={1250-4}
}
Recent studies performed in Japan have suggested that hepatitis C virus (HCV) genome heterogeneity might be taken as a predictive virological parameter of response to interferon alfa (IFN-alpha) treatment. However, there is presently no information on the impact of this virological parameter in patients from Western countries infected by different HCV genotypes. We have investigated this issue by using amplification of HCV E2 hypervariable region 1, followed by single-strand conformation… CONTINUE READING