Hepatitis C virus fails to activate NF-κB signaling in plasmacytoid dendritic cells.

  title={Hepatitis C virus fails to activate NF-κB signaling in plasmacytoid dendritic cells.},
  author={Cl{\'e}lia Dental and Jonathan Florentin and Besma Aouar and Françoise Gondois-Rey and David Durantel and Thomas F Baumert and Jacques A Nun{\`e}s and Daniel Olive and Ivan Hirsch and Rů{\vz}ena Str{\'a}nsk{\'a}},
  journal={Journal of virology},
  volume={86 2},
Plasmacytoid dendritic cells (pDCs) respond to viral infection by production of alpha interferon (IFN-α), proinflammatory cytokines, and cell differentiation. The elimination of hepatitis C virus (HCV) in more than 50% of chronically infected patients by treatment with IFN-α suggests that pDCs can play an important role in the control of HCV infection. pDCs exposed to HCV-infected hepatoma cells, in contrast to cell-free HCV virions, produce large amounts of IFN-α. To further investigate the… CONTINUE READING
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