Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy.

@article{Binder2007HepatitisCV,
  title={Hepatitis C virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy.},
  author={Marco Binder and Georg Kochs and Ralf Bartenschlager and Volker Lohmann},
  journal={Hepatology},
  year={2007},
  volume={46 5},
  pages={1365-74}
}
UNLABELLED Hepatitis C virus (HCV) has been known to replicate with extremely varying efficiencies in different host cells, even within different populations of a single human hepatoma cell line, termed Huh-7. Several reports have implicated the retinoic-acid inducible gene I (RIG-I)/ interferon regulatory factor 3 (IRF-3) pathway of the innate antiviral response with differences in host cell permissiveness to HCV. To investigate the general impact of the IRF-3 response onto HCV replication in… CONTINUE READING
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