Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum.

@article{Benedicto2008HepatitisCV,
  title={Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum.},
  author={Ignacio Benedicto and Francisca Molina-Jim{\'e}nez and Olga Barreiro and Alejandra Maldonado-Rodr{\'i}guez and Jes{\'u}s Prieto and Ricardo Moreno-Otero and Rafael Aldabe and Manuel L{\'o}pez-Cabrera and Pedro Lorenzo Majano},
  journal={Hepatology},
  year={2008},
  volume={48 4},
  pages={1044-53}
}
UNLABELLED Hepatocyte tight junctions (TJ) play key roles in characteristic liver functions, including bile formation and secretion. Infection by hepatitis C virus (HCV) may cause alterations of the liver architecture and disruption of the bile duct, which ultimately can lead to cholestasis. Herein, we employed the HCV replicon system to analyze the effect of HCV on TJ organization. TJ-associated proteins occludin, claudin-1, and Zonula Occludens protein-1 (ZO-1) disappeared from their normal… CONTINUE READING

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