Hepatitis C virus entry requires a critical postinternalization step and delivery to early endosomes via clathrin-coated vesicles.

@article{Meertens2006HepatitisCV,
  title={Hepatitis C virus entry requires a critical postinternalization step and delivery to early endosomes via clathrin-coated vesicles.},
  author={Laurent Meertens and Claire Bertaux and Tatjana Dragic},
  journal={Journal of virology},
  year={2006},
  volume={80 23},
  pages={11571-8}
}
Hepatitis C virus (HCV) is a major human pathogen associated with life-threatening liver disease. Entry into hepatocytes requires CD81 and a putative second receptor. In this study, we elucidated the postreceptor attachment stages of HCV entry using HCV pseudoparticles (HCVpp) as a model system. By means of dominant-negative mutants and short interfering… CONTINUE READING