Hepatitis C virus entry and neutralization.

  title={Hepatitis C virus entry and neutralization.},
  author={Zania Stamataki and Joe Grove and Peter Balfe and Jane A McKeating},
  journal={Clinics in liver disease},
  volume={12 3},
  pages={693-712, x}
The processes of hepatitis C virus (HCV) entry and antibody-mediated neutralization are intimately linked. The high frequency of neutralizing antibodies (nAbs) that inhibit E2-CD81 interaction(s) suggests that this is a major target for the humoral immune response. The observation that HCV can transmit to naive cells by means of CD81-dependent and -independent routes in vitro awaits further investigation to assess the significance in vivo but may offer new strategies for HCV to escape nAbs. The… CONTINUE READING


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