Hepatitis C virus dynamics in vivo: effect of ribavirin and interferon alfa on viral turnover.

@article{Zeuzem1998HepatitisCV,
  title={Hepatitis C virus dynamics in vivo: effect of ribavirin and interferon alfa on viral turnover.},
  author={Stefan Zeuzem and Jamey Maimares Schmidt and J H Lee and Michael von Wagner and Gerlinde Teuber and W. Kurt Roth},
  journal={Hepatology},
  year={1998},
  volume={28 1},
  pages={245-52}
}
Treatment of patients with chronic hepatitis C with recombinant interferon alfa (rIFN-alpha) can cause a decrease of serum transaminases and hepatitis C virus (HCV) RNA. Recent trials evaluating combination therapy of IFN-alpha and ribavirin suggested a potential synergistic effect. From serial measurements of serum HCV RNA concentrations following treatment-induced perturbation of the balance between virus production and clearance, we compared the antiviral efficacy of both IFN-alpha alone and… CONTINUE READING

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