Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes.

@article{Nguyen2006HepatitisCV,
  title={Hepatitis C virus core protein induces expression of genes regulating immune evasion and anti-apoptosis in hepatocytes.},
  author={Hau Nguyen and Sumathi Sankaran and Satya Dandekar},
  journal={Virology},
  year={2006},
  volume={354 1},
  pages={58-68}
}
Hepatitis C virus (HCV) Core protein is implicated in the development of hepatocellular carcinoma (HCC). We utilized a HepG2 human hepatocyte cell line with inducible expression of HCV Core protein (HCV-1b) to investigate the early effects of Core protein on hepatocyte gene expression and to identify molecular processes modulated by the Core protein. A significant change was observed in the expression of 407 genes, which included genes regulating apoptosis, immune response, and cell cycle. Some… CONTINUE READING