Hepatitis C virus core protein genotype 3a increases SOCS-7 expression through PPAR-{gamma} in Huh-7 cells.

@article{Pazienza2010HepatitisCV,
  title={Hepatitis C virus core protein genotype 3a increases SOCS-7 expression through PPAR-\{gamma\} in Huh-7 cells.},
  author={Valerio Pazienza and Manlio Vinciguerra and Angelo Andriulli and A Mangia},
  journal={The Journal of general virology},
  year={2010},
  volume={91 Pt 7},
  pages={1678-86}
}
Hepatitis C virus (HCV) core protein genotype 3a induces the expression of suppressor of cytokine signalling protein 7 (SOCS-7), which is partially involved in the development of insulin resistance. The aim of the present study was to investigate the mechanism through which the core protein regulates SOCS-7 expression. We have explored, in the in vitro model of Huh-7 cells expressing the HCV core protein of genotype 3a, whether the expression of SOCS-7 as well as of other members of the SOCS… CONTINUE READING
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