Hepatitis C virus core protein enhances hepatocellular carcinoma cells to be susceptible to oncolytic vesicular stomatitis virus through down-regulation of HDAC4.

@article{Moon2016HepatitisCV,
  title={Hepatitis C virus core protein enhances hepatocellular carcinoma cells to be susceptible to oncolytic vesicular stomatitis virus through down-regulation of HDAC4.},
  author={Jeong Moon and Sirichat Kaowinn and Il-Rae Cho and Do Sik Min and Heejoon Myung and Sangtaek Oh and Chutima Kaewpiboon and Olive H Kraemer and Y K Chung},
  journal={Biochemical and biophysical research communications},
  year={2016},
  volume={474 3},
  pages={428-434}
}
Since hepatitis C virus (HCV) core protein is known to possess potential oncogenic activity, we explored whether oncolytic vesicular stomatitis virus (VSV) could efficiently induce cytolysis in hepatocellular carcinoma cells stably expressing HCV core protein (Hep3B-Core). We found that Hep3B-Core cells were more susceptible to VSV as compared to control… CONTINUE READING