Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha.

Abstract

Persistent hepatitis C virus (HCV) infection is associated with the development of human hepatocellular carcinoma (HCC), although the mechanism of HCV-related hepatocarcinogenesis remains unclear. Recently, however, the close relationships between the development of HCC and the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated protein… (More)

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@article{Hayashi2000HepatitisCV, title={Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha.}, author={Jun Hayashi and Hideo Aoki and Kentaro Kajino and Mariko Moriyama and Y. Arakawa and Okio Hino}, journal={Hepatology}, year={2000}, volume={32 5}, pages={958-61} }