Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expression.

@article{Wang2014HepatitisCV,
  title={Hepatitis C virus core protein activates autophagy through EIF2AK3 and ATF6 UPR pathway-mediated MAP1LC3B and ATG12 expression.},
  author={Ji Wang and Rongyan Kang and He Huang and Xueyan Xi and Bei Wang and Jianwei Wang and Zhendong Zhao},
  journal={Autophagy},
  year={2014},
  volume={10 5},
  pages={766-84}
}
HCV infection induces autophagy, but how this occurs is unclear. Here, we report the induction of autophagy by the structural HCV core protein and subsequent endoplasmic reticular (ER) stress in Huh7 hepatoma cells. During ER stress, both the EIF2AK3 and ATF6 pathways of the unfolded protein response (UPR) were activated by HCV core protein. Then, these… CONTINUE READING