Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.

@article{Otani2005HepatitisCV,
  title={Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells.},
  author={K. Otani and M. Korenaga and M. R. Beard and K. Li and T. Qian and L. A. Showalter and A. K. Singh and Ting Wang and S. Weinman},
  journal={Gastroenterology},
  year={2005},
  volume={128 1},
  pages={
          96-107
        }
}
  • K. Otani, M. Korenaga, +6 authors S. Weinman
  • Published 2005
  • Medicine
  • Gastroenterology
  • BACKGROUND & AIMS Alcohol consumption exacerbates liver injury in chronic hepatitis C, and enhanced mitochondrial oxidative stress is one possible mechanism. The aim of this study was to determine whether hepatitis C virus core protein and alcohol-inducible cytochrome P450 2E1 contribute to reactive oxygen species production and cytotoxicity in human hepatoma cells. METHODS Huh-7 cells expressing core protein, cytochrome P450 2E1, or both were exposed to 0.1 mmol/L tertiary butyl… CONTINUE READING

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