Hepatitis C virus activation in HIV-infected patients initiating highly active antiretroviral therapy.

Abstract

We describe repeated episodes of hepatitis C (HCV) activation associated with initiation of highly active antiretroviral therapy (HAART) in two HIV/HCV coinfected individuals with undetectable serum HCV RNA. Both patients developed high HCV viremia (>1 million IU/mL) and elevations in aminotransferases >10 times upper limit of normal) within 4 months of starting HAART. This is the first report of clinically significant HCV activation in HCV-seropositive patients with initially undetectable HCV viremia. These observations suggest that flares of hepatitis C in the setting of the immune reconstitution inflammatory syndrome can occur even in those patients who have undetectable serum HCV levels prior to HAART initiation.

Cite this paper

@article{Kim2007HepatitisCV, title={Hepatitis C virus activation in HIV-infected patients initiating highly active antiretroviral therapy.}, author={H. Nina Kim and Robert D Harrington and Margaret C. Shuhart and Linda Sue Cook and Chihiro Morishima and Keith R. Jerome and Chia Ching Wang}, journal={AIDS patient care and STDs}, year={2007}, volume={21 10}, pages={718-23} }