Hepatitis C virus NS5A protein inhibits interferon antiviral activity, but the effects do not correlate with clinical response.

@article{Paterson1999HepatitisCV,
  title={Hepatitis C virus NS5A protein inhibits interferon antiviral activity, but the effects do not correlate with clinical response.},
  author={M. Paterson and C. Laxton and H. Thomas and A. Ackrill and G. Foster},
  journal={Gastroenterology},
  year={1999},
  volume={117 5},
  pages={
          1187-97
        }
}
BACKGROUND & AIMS Patients with chronic hepatitis C virus infection are commonly treated with interferon alfa (IFN-alpha), but the long-term response rate is poor. A region of NS5A of hepatitis C virus genotype 1 (the ISDR) has been associated with treatment outcome in some patients. NS5A binds to and inhibits PKR in vitro and inhibits IFN-alpha in human cells. We examined the effects of the NS5A protein from patients who did or did not respond to IFN-alpha to determine whether NS5A from IFN… Expand
Hepatitis C Virus Nonstructural 5A Protein Induces Interleukin-8, Leading to Partial Inhibition of the Interferon-Induced Antiviral Response
  • Stephen J. Polyak, Khalid S. A. Khabar, +6 authors David R. Gretch
  • Biology, Medicine
  • Journal of Virology
  • 2001
Suppression of interferon-induced antiviral activity in cells expressing hepatitis C virus proteins.
  • H. Aizaki, S. Saito, +5 authors M. Kohase
  • Medicine, Biology
  • Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research
  • 2000
Reduced expression of Jak-1 and Tyk-2 proteins leads to interferon resistance in Hepatitis C virus replicon
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