Hepatitis C virus 3'X region interacts with human ribosomal proteins.

  title={Hepatitis C virus 3'X region interacts with human ribosomal proteins.},
  author={Jonny Wood and R M Frederickson and Stanley Fields and Arvind H Patel},
  journal={Journal of virology},
  volume={75 3},
To identify proteins that can bind the 3' untranslated region (UTR) of hepatitis C virus (HCV) we screened human cDNA libraries using the Saccharomyces cerevisiae three-hybrid system. Screening with an RNA sequence derived from the 3'-terminal 98 nucleotides (3'X region) of an infectious clone of HCV (H77c) yielded clones of human ribosomal proteins L22, L3, S3, and mL3, a mitochondrial homologue of L3. We performed preliminary characterization of the binding between the 3'X region and these… CONTINUE READING


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