Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress.

@article{Garaigorta2012HepatitisCV,
  title={Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress.},
  author={Urtzi Garaigorta and Markus H Heim and Bryan Boyd and Stefan D Wieland and Francis V. Chisari},
  journal={Journal of virology},
  year={2012},
  volume={86 20},
  pages={11043-56}
}
Stress granules (SGs) are cytoplasmic structures that are induced in response to environmental stress, including viral infections. Here we report that hepatitis C virus (HCV) triggers the appearance of SGs in a PKR- and interferon (IFN)-dependent manner. Moreover, we show an inverse correlation between the presence of stress granules and the induction of IFN-stimulated proteins, i.e., MxA and USP18, in HCV-infected cells despite high-level expression of the corresponding MxA and USP18 mRNAs… CONTINUE READING