Hepatitis C virus (HCV)--specific T cell responses in injection drug users with apparent resistance to HCV infection.

@article{Thurairajah2008HepatitisCV,
  title={Hepatitis C virus (HCV)--specific T cell responses in injection drug users with apparent resistance to HCV infection.},
  author={Prem H Thurairajah and Doha Hegazy and Shilpa Chokshi and Steve G. Shaw and Andrew Demaine and Edward R Kaminski and Nikolai V. Naoumov and Matthew E Cramp},
  journal={The Journal of infectious diseases},
  year={2008},
  volume={198 12},
  pages={1749-55}
}
BACKGROUND Injection drug users (IDUs) are at risk of acquiring hepatitis C virus (HCV) infection. We have identified a cohort of long-term IDUs who remain uninfected by HCV despite high-risk behavior. We have categorized these subjects as "exposed uninfected" and have sought immunological correlates with this apparent resistance. METHODS We studied 40 exposed uninfected subjects testing negative for both HCV antibody and HCV RNA. Details of injection behavior were ascertained by… CONTINUE READING