Hepatitis C quantification and sequencing in blood products, haemophiliacs, and drug users.

@article{Simmonds1990HepatitisCQ,
  title={Hepatitis C quantification and sequencing in blood products, haemophiliacs, and drug users.},
  author={Peter Simmonds and Lin Zhang and H Geoffrey Watson and Selma Rebus and Elaine D. Ferguson and Peter Balfe and Guy Leadbetter and Peng Lee Yap and J F Peutherer and Christopher A. Ludlam},
  journal={Lancet},
  year={1990},
  volume={336 8729},
  pages={1469-72}
}
The polymerase chain reaction (PCR) detected specific hepatitis C viral (HCV) RNA sequences in plasma from 15 of 21 haemophiliacs (12 HCV-antibody positive) and 7 of 27 intravenous drug users (13 HCV-antibody positive). Quantification of RNA-positive samples showed high levels of HCV (10(5) to 10(6) copies of RNA/ml) in infected patients. HCV was more frequently found in haemophiliacs infected with human immunodeficiency virus (11/11 HIV-positive and 4/10 HIV-negative patients). HCV-RNA was… CONTINUE READING
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