Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: genetic subtype defines antigenic but not neutralization serotype.

@article{Tarr2011HepatitisCP,
  title={Hepatitis C patient-derived glycoproteins exhibit marked differences in susceptibility to serum neutralizing antibodies: genetic subtype defines antigenic but not neutralization serotype.},
  author={Alexander W. Tarr and Richard A. Urbanowicz and Mohamed Belal Hamed and Anna Albecka and C. Patrick McClure and Richard J. Brown and William Lucien Irving and Jean Dubuisson and Jonathan K. Ball},
  journal={Journal of virology},
  year={2011},
  volume={85 9},
  pages={4246-57}
}
Neutralizing antibodies have a role in controlling hepatitis C virus (HCV) infection. A successful vaccine will need to elicit potently neutralizing antibodies that are capable of preventing the infection of genetically diverse viral isolates. However, the specificity of the neutralizing antibody response in natural HCV infection still is poorly understood. To address this, we examined the reactivity of polyclonal antibodies isolated from chronic HCV infection to the diverse patient-isolated… CONTINUE READING
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