Hepatitis C coinfection enhances sensitization of CD4(+) T-cells towards Fas-induced apoptosis in viraemic and HAART-controlled HIV-1-positive patients.

@article{Koerner2011HepatitisCC,
  title={Hepatitis C coinfection enhances sensitization of CD4(+) T-cells towards Fas-induced apoptosis in viraemic and HAART-controlled HIV-1-positive patients.},
  author={Christian Koerner and Felix Tolksdorf and Katarina Riesner and Benjamin Kr{\"a}mer and Daniela Schulte and Jacob Nattermann and J{\"u}rgen K. Rockstroh and Ulrich Spengler},
  journal={Antiviral therapy},
  year={2011},
  volume={16 7},
  pages={
          1047-55
        }
}
BACKGROUND Recently, we identified increased rates of CD4(+) T-cell apoptosis in HCV-infected HIV-positive patients as a potential mechanism for enhanced mortality in patients with HIV/HCV coinfection. Since this effect might be attributed to changes in receptor-induced apoptosis, we studied expression and function of Fas ligand (FasL) and its death receptor Fas on CD4(+) T-cells in HIV/HCV coinfection. METHODS In this cross-sectional study, we simultaneously analysed surface expression of… CONTINUE READING

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