Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system

@article{Fiore2005HepatitisCO,
  title={Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system},
  author={Carmelo Erio Fiore and Stefania Riccobene and Roberto Antonio Mangiafico and Ferrucio Santoro and Pietra Pennisi},
  journal={Osteoporosis International},
  year={2005},
  volume={16},
  pages={2180-2184}
}
We report a new case of hepatitis C-associated osteosclerosis (HCAO). The clinical presentation of the patient was an acquired deep severe bone pain with increased serum bone alkaline phosphatase activity (up to 12 times the upper limit of normal), and generalized bone sclerosis, temporally related to the hepatitis C-virus (HCV) infection. We documented in this patient an increase of circulating osteoprotegerin (OPG), and a concentration of circulating receptor activator for nuclear factor-kB… 
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References

SHOWING 1-10 OF 25 REFERENCES
Hepatitis C-associated osteosclerosis: late onset after blood transfusion in an elderly woman.
TLDR
It is found that bone mass can be restored by this disorder in a postmenopausal woman and understanding and control of the mechanism of HC-associated osteosclerosis could potentially lead to correction of low bone mass from osteoporosis with good quality skeletal tissue.
Use of site-specific antibodies to characterize the circulating form of big insulin-like growth factor II in patients with hepatitis C-associated osteosclerosis.
TLDR
It is demonstrated that HCAO patients have a specific increase in circulating big IGF-II (IGf-IIE) and IGF-binding protein-2 (IGFBP-2) levels, and that IGF- IIE and IGF BP-2 circulate together in a bioavailable, 50-kDa complex.
Painful diffuse osteosclerosis after intravenous drug abuse.
Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults.
TLDR
IGBP-2 may facilitate the targeting of IGFs, and in particular IGF-IIE, to skeletal tissue in HCAO patients, with a subsequent stimulation by IGFs of osteoblast function, suggesting a possible means to increase bone mass in patients with osteoporosis.
Doubling skeletal mass during adult life: The syndrome of diffuse osteosclerosis after intravenous drug abuse
  • M. Whyte, S. Teitelbaum, W. Reinus
  • Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1996
TLDR
It is shown that skeletal mass can be markedly increased with histologically normal, structurally sound bone during adult life and elucidation of the etiology and pathogenesis could offer an effective treatment for osteoporosis.
High serum osteoprotegerin and low RANKL in primary biliary cirrhosis.
Creatine kinase brain isoenzyme (BB‐CK) presence in serum distinguishes osteopetroses among the sclerosing bone disorders
TLDR
ABSTRACT: Absence of serum BB‐CK in adult type I disease suggests that this condition may not be a genuine form of OP, and quantitated total CK activity and CK isoenzymes in 15 patients representing the five major clinical forms of OP and in 22 patients representing 14 other types of sclerosing bone disease.
Intrahepatic expression of c-fos, c-myb and c-myc oncogenes: correlation with virus-induced chronic liver disease and response to interferon.
TLDR
Intrahepatic c-fos and c-myb were detected in chronic viral hepatitis patients, but not in non-viral liver diseases, and their expression correlated with the grade and stage of liver disease and with poor response to alpha-IFN.
Minireview: the OPG/RANKL/RANK system.
TLDR
The identification of the OPG-ligand/osteoclast differentiating factor and subsequently RANKL, was identified as the key mediator of osteoclastogenesis in both a membrane-bound form expressed on preosteoblastic/stromal cells as well as a soluble form.
...
1
2
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