Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system

@article{Fiore2005HepatitisCO,
  title={Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system},
  author={Carmelo Erio Fiore and Stefania Riccobene and Roberto Antonio Mangiafico and Ferrucio Santoro and Pietra Pennisi},
  journal={Osteoporosis International},
  year={2005},
  volume={16},
  pages={2180-2184}
}
We report a new case of hepatitis C-associated osteosclerosis (HCAO). The clinical presentation of the patient was an acquired deep severe bone pain with increased serum bone alkaline phosphatase activity (up to 12 times the upper limit of normal), and generalized bone sclerosis, temporally related to the hepatitis C-virus (HCV) infection. We documented in this patient an increase of circulating osteoprotegerin (OPG), and a concentration of circulating receptor activator for nuclear factor-kB… 
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27 Citations

Hepatitis C-Associated Osteosclerosis: Improvement After Treatment with Sofosbuvir, Daclatasvir, and Ibandronate: Case Report and Literature Review.
TLDR
The case of a 59-year-old man with generalized bone pain and diagnosis of HCV infection, sequentially treated with cholecalciferol, prednisone, sofosbuvir associated with daclatasvir and ibandronate is reported.
Hepatitis C-associated osteosclerosis: a new case with long-term follow-up and a review of the literature.
TLDR
The case of a 61-year-old woman affected by severe pain involving the lower limbs is described and a normalized radioisotope uptake on bone scanning 10 years after the diagnosis of hepatitis C-associated osteosclerosis is discussed.
An uncommon cause of acquired osteosclerosis in adults: hepatitis C-associated osteosclerosis
TLDR
Clinical presentation and imaging results of the 19th case of Hepatitis C-associated osteosclerosis are reported, finding that the etio-pathogenesis remains obscure but may bear important lessons in bone biology that could lead to new treatment options for osteoporosis.
A case of hepatitis C-associated osteosclerosis that was improved with the combination therapy of peginterferon alfa-2b and ribavirin
TLDR
Hepatitis C-associated osteosclerosis was improved by the combination therapy of peginterferon alfa-2b and ribavirin when the patient achieved sustained virological response.
A case of hepatitis C-associated osteosclerosis with xanthogranulomatous cholecystitis.
TLDR
A 62-year-old woman presented with a markedly increased serum ALP level of skeletal origin during a regular follow-up of chronic hepatitis C and histopathological findings demonstrated xanthogranulomatous cholecystitis, which may indicate the existence of a novel osteogenic factor in the gallbladder in HCAO.
A case of hepatitis C-associated osteosclerosis in an elderly Japanese man.
TLDR
An elderly Japanese man with HCAO, whose clinical course the authors followed for 3 years, and previous reports suggest that the skeletal tissue of this disease appears to be of good quality.
Skeletal recovery from hepatitis C-associated osteosclerosis (HCAO) following antiviral treatment.
Rheumatologic Symptoms in Patients with Mixed Cryoglobulinemia
TLDR
The main rheumatic symptoms that can occur during MC (HCV chronic infection) are reviewed and the principles underlying their clinical management are discussed.
Terpos Osteoporosis and osteosclerosis in sickle cell / β-thalassemia : the role of the RANKL / osteoprotegerin axis
TLDR
Evaluated the bone mineral density (BMD) of HbS/β-thalassemia patients in parallel with markers of bone remodeling in an attempt to better understand the pathophysiology of bone disease in these patients.
Serum Sclerostin in Hepatitis C Virus Infected Patients
TLDR
Serum sclerostin levels were within the normal range in HCV patients, and correlated directly with BMD and serum telopeptide, and the role of bones for intermediary metabolisms was suggested.
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