Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission.

@article{Giugliano2015HepatitisCV,
  title={Hepatitis C Virus Sensing by Human Trophoblasts Induces Innate Immune Responses and Recruitment of Maternal NK Cells: Potential Implications for Limiting Vertical Transmission.},
  author={Silvia Giugliano and Margaret G. Petroff and Bryce D. Warren and Susmita Jasti and Caitlin Linscheid and Ashley Ward and Anita W Kramer and Evgenia Dobrinskikh and Melissa A. Sheiko and Michael Gale and Lucy Golden-Mason and Virginia D Winn and Hugo R Rosen},
  journal={Journal of immunology},
  year={2015},
  volume={195 8},
  pages={3737-47}
}
Hepatitis C virus (HCV) is the world's most common blood-borne viral infection for which there is no vaccine. The rates of vertical transmission range between 3 and 6% with odds 90% higher in the presence of HIV coinfection. Prevention of vertical transmission is not possible because of lack of an approved therapy for use in pregnancy or an effective vaccine. Recently, HCV has been identified as an independent risk factor for preterm delivery, perinatal mortality, and other complications. In… CONTINUE READING