Hepatitis C Virus RNA Replication Depends on Specific Cis- and Trans-Acting Activities of Viral Nonstructural Proteins

@inproceedings{Kazakov2015HepatitisCV,
  title={Hepatitis C Virus RNA Replication Depends on Specific Cis- and Trans-Acting Activities of Viral Nonstructural Proteins},
  author={Teymur Kazakov and Feng Yang and Harish N. Ramanathan and Andrew S. Kohlway and Michael S Diamond and Brett Lindenbach},
  booktitle={PLoS pathogens},
  year={2015}
}
Many positive-strand RNA viruses encode genes that can function in trans, whereas other genes are required in cis for genome replication. The mechanisms underlying trans- and cis-preferences are not fully understood. Here, we evaluate this concept for hepatitis C virus (HCV), an important cause of chronic liver disease and member of the Flaviviridae family. HCV encodes five nonstructural (NS) genes that are required for RNA replication. To date, only two of these genes, NS4B and NS5A, have been… CONTINUE READING

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