Hepatitis C Virus Evolutionary Patterns Studied Through Analysis of Full-Genome Sequences

  title={Hepatitis C Virus Evolutionary Patterns Studied Through Analysis of Full-Genome Sequences},
  author={Marco Salemi and Anne-Mieke Vandamme},
  journal={Journal of Molecular Evolution},
Abstract. The evolutionary patterns of hepatitis C virus (HCV), including the best-fitting nucleotide substitution model and the molecular clock hypothesis, were investigated by analyzing full-genome sequences available in the HCV database. The likelihood ratio test allowed us to discriminate among different evolutionary hypotheses. The phylogeny of the six major HCV types was accurately inferred, and the final tree was rooted by reconstructing the hypothetical HCV common ancestor with the… 
The mode and tempo of hepatitis C virus evolution within and among hosts
BackgroundHepatitis C virus (HCV) is a rapidly-evolving RNA virus that establishes chronic infections in humans. Despite the virus' public health importance and a wealth of sequence data, basic
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This review discusses the application of theoretical frameworks to the interpretation of viral gene sequence data and argues that these approaches are invaluable tools to the virologist and are essential for understanding the dynamics of viral infection and the outcome of therapeutic strategies.
Phylogeny and molecular evolution of the hepatitis C virus.
Reconstruction of the evolutionary dynamics of the hepatitis C virus 1b epidemic in Turkey.
  • M. Ciccozzi, A. Ciccaglione, G. Zehender
  • Biology
    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
  • 2011
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At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide.
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Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis.
The nucleotide sequence of the Japanese type of hepatitis C virus (HCV-J) genome, consisting of 9413 nucleotides, was determined by analyses of cDNA clones from plasma specimens from Japanese
Evolutionary Rate and Genetic Drift of Hepatitis C Virus Are Not Correlated with the Host Immune Response: Studies of Infected Donor-Recipient Clusters
The results seem to imply that genetic drift is less dependent on immune pressure than on the rate of evolution and that the genetic drift of HCV is independent of the host immune pressure.
Revealing the history of infectious disease epidemics through phylogenetic trees.
Despite similarities between these viruses, especially in their transmission routes, they have very different epidemiological histories, and a possible reason for the difference is that HCV has coexisted longer with human populations.
Evolutionary analysis of variants of hepatitis C virus found in South-East Asia: comparison with classifications based upon sequence similarity.
Variants of hepatitis C virus (HCV) have been classified by nucleotide sequence comparisons in different regions of the genome. Many investigators have defined the ranges of sequence similarity
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sequence analysis of variants in the 5' non-coding region (5'NCR) and in the genes encoding the core protein, an envelope protein (E1) and a non-structural protein (NS-5) indicate that subgenomic regions such as E1 and NS-5 contain sufficient phylogenetic information for the identification of each of the 11 or 12 known types and subtypes of HCV.
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