Hepatitis C Virus Evolutionary Patterns Studied Through Analysis of Full-Genome Sequences

  title={Hepatitis C Virus Evolutionary Patterns Studied Through Analysis of Full-Genome Sequences},
  author={M. Salemi and A. Vandamme},
  journal={Journal of Molecular Evolution},
  • M. Salemi, A. Vandamme
  • Published 2002
  • Biology, Medicine
  • Journal of Molecular Evolution
  • Abstract. The evolutionary patterns of hepatitis C virus (HCV), including the best-fitting nucleotide substitution model and the molecular clock hypothesis, were investigated by analyzing full-genome sequences available in the HCV database. The likelihood ratio test allowed us to discriminate among different evolutionary hypotheses. The phylogeny of the six major HCV types was accurately inferred, and the final tree was rooted by reconstructing the hypothetical HCV common ancestor with the… CONTINUE READING

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