Hepatitis C Virus Core Protein Inhibits Mitochondrial Electron Transport and Increases Reactive Oxygen Species (ROS) Production*

@article{Korenaga2005HepatitisCV,
  title={Hepatitis C Virus Core Protein Inhibits Mitochondrial Electron Transport and Increases Reactive Oxygen Species (ROS) Production*},
  author={M. Korenaga and Ting Wang and Yanchun Li and L. Showalter and T. Chan and Jiaren Sun and S. Weinman},
  journal={Journal of Biological Chemistry},
  year={2005},
  volume={280},
  pages={37481 - 37488}
}
Hepatitis C infection causes a state of chronic oxidative stress, which may contribute to fibrosis and carcinogenesis in the liver. Previous studies have shown that expression of the HCV core protein in hepatoma cells depolarized mitochondria and increased reactive oxygen species (ROS) production, but the mechanisms of these effects are unknown. In this study we examined the properties of liver mitochondria from transgenic mice expressing HCV core protein, and from normal liver mitochondria… Expand
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