Hepatitis C Virus Core Protein Induces Lipid Droplet Redistribution in a Microtubule‐ and Dynein‐Dependent Manner

@article{Boulant2008HepatitisCV,
  title={Hepatitis C Virus Core Protein Induces Lipid Droplet Redistribution in a Microtubule‐ and Dynein‐Dependent Manner},
  author={Steeve Boulant and Mark W. Douglas and Laura Moody and Agata Budkowska and Paul Targett-Adams and John McLauchlan},
  journal={Traffic},
  year={2008},
  volume={9}
}
Attachment of hepatitis C virus (HCV) core protein to lipid droplets (LDs) is linked to release of infectious progeny from infected cells. Core progressively coats the entire LD surface from a unique site on the organelle, and this process coincides with LD aggregation around the nucleus. We demonstrate that LD redistribution requires only core protein and is accompanied by reduced abundance of adipocyte differentiation‐related protein (ADRP) on LD surfaces. Using small hairpin RNA technology… 
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TLDR
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TLDR
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Dynamics of lipid droplets induced by the hepatitis C virus core protein.
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TLDR
Novel insights are provided into the sequence of HCV assembly events and essential functions of p7 to support a model where capsid assembly is linked with membrane envelopment of nascent RNA-containing core protein multimers, a process coordinated by p7.
lncRNA HULC facilitates efficient loading of HCV‐core protein onto lipid droplets and subsequent virus‐particle release
TLDR
A distinct role of long noncoding RNA HULC is identified in lipid dynamics during HCV infection, which provides new insights into the complex process of HCV propagation and pathogenesis.
Initiation of Hepatitis C Virus Infection Requires the Dynamic Microtubule Network
TLDR
HCV may exploit a direct interaction of core with tubulin, enhancing microtubule polymerization, to establish efficient infection and promote virus transport and/or assembly in infected cells.
Bidirectional Lipid Droplet Velocities Are Controlled by Differential Binding Strengths of HCV Core DII Protein
TLDR
Results for DII-core coated LDs support a model for core-mediated LD localization that involves core slowing down the rate of movement of LDs until localization at the perinuclear region is accomplished where LD movement ceases.
A Concerted Action of Hepatitis C Virus P7 and Nonstructural Protein 2 Regulates Core Localization at the Endoplasmic Reticulum and Virus Assembly
Hepatitis C virus (HCV) assembly remains a poorly understood process. Lipid droplets (LDs) are thought to act as platforms for the assembly of viral components. The JFH1 HCV strain replicates and
PIAS1 Regulates Hepatitis C Virus-Induced Lipid Droplet Accumulation by Controlling Septin 9 and Microtubule Filament Assembly
TLDR
It is shown that the infection of HCC-derived Huh7.5 cells with HCV promotes upregulation of the protein inhibitor of activated STAT1 (PIAS1) and this data reveal that PIAS1 regulates the accumulation of lipid droplets and offer a meaningful insight into how HCV interacts with host proteins.
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