Hepatitis C: the end of the beginning and possibly the beginning of the end.

@article{Alter2012HepatitisCT,
  title={Hepatitis C: the end of the beginning and possibly the beginning of the end.},
  author={Harvey J. Alter and Tehming Liang},
  journal={Annals of internal medicine},
  year={2012},
  volume={156 4},
  pages={317-8}
}
the End Not since the initial cloning of the hepatitis C virus (HCV) in 1989 and the subsequent development of assays to detect silent carriers (1) and protect the blood supply (2) have data on this infection been so exciting. Before 1990, HCV was an incurable, prevalent chronic infection and had only a 10% cure rate with early interferon monotherapy. Sustained virologic response (SVR) rates—which are tantamount to cure—increased to approximately 25% by adding ribavirin and 45% when pegylated… CONTINUE READING
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References

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Showing 1-10 of 18 references

Dual therapy with the NS 5 A inhibitor BMS790052 and the NS 3 protease inhibitor BMS650032 in HCV genotype 1 binfected null responders

  • K Chayama, S Takahashi, J Toyota, Y Karino, K Ikeda, H Ishikawa
  • Hepatology
  • 2011

Dual therapy with the NS5A inhibitor BMS-790052 and the NS3 protease inhibitor BMS-650032 in HCV genotype 1b-infected null responders. Hepatology

  • K Chayama, S Takahashi, J Toyota, Y Karino, K Ikeda, H Ishikawa
  • [PMID:
  • 2011
1 Excerpt

SPRINT-2 Investigators. Boceprevir for untreated chronic HCV genotype 1 infection

  • F Poordad, J JrMcCone, BR Bacon, S Bruno, MP Manns, MS Sulkowski
  • N Engl J Med. 2011;364:1195-206
  • 2011
1 Excerpt

The protease inhibitor GS-9256 and non-nucleoside polymerase inhibitor tegobuvir alone, with RBV or peginterferon plus RBV in hepatitis

  • S Zeuzem, P Buggisch, K Agarwal, P Marcellin, D Sereni, H Klinker
  • C. Hepatology
  • 2011
3 Excerpts

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