Hepatitis C: progress and problems.

@article{Cuthbert1994HepatitisCP,
  title={Hepatitis C: progress and problems.},
  author={Jennifer A. Cuthbert},
  journal={Clinical microbiology reviews},
  year={1994},
  volume={7 4},
  pages={
          505-32
        }
}
The hepatitis C virus (HCV), a single-stranded RNA virus, is the major cause of posttransfusion hepatitis. HCV isolates differ in nucleotide and amino acid sequences. Nucleotide changes are concentrated in hypervariable regions and may be related to immune selection. In most immunocompetent persons, HCV infection is diagnosed serologically, using antigens from conserved regions. Amplification of RNA may be necessary to detect infection in immunosuppressed patients. Transmission by known… CONTINUE READING

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