Hepatitis B virus variants with lamivudine-related mutations in the DNA polymerase and the 'a' epitope of the surface antigen are sensitive to ganciclovir.

@article{Oon1999HepatitisBV,
  title={Hepatitis B virus variants with lamivudine-related mutations in the DNA polymerase and the 'a' epitope of the surface antigen are sensitive to ganciclovir.},
  author={Chong Jin Oon and Wei Ning Chen and N Lim and Shiuan Koh and Gek Keow Lim and Ai Lin Leong and Gek San Tan},
  journal={Antiviral research},
  year={1999},
  volume={41 3},
  pages={113-8}
}
Lamivudine is a new antiviral agent effective against hepatitis B viral (HBV) infections but can result in virus-drug resistance associated with mutations in the conserved 'YM552DD' motif of the HBV DNA polymerase. Due to their overlapping coding regions in the HBV genome, mutations in the DNA polymerase may result in substitutions in the hepatitis B surface antigen (HBsAg), albeit outside the antigenic 'a' epitope. Here we report the identification of a novel type of lamivudine-related… CONTINUE READING