Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH.

@article{Qadri1996HepatitisBV,
  title={Hepatitis B virus transactivator protein, HBx, associates with the components of TFIIH and stimulates the DNA helicase activity of TFIIH.},
  author={Ishtiaq Qadri and Joan W Conaway and Ronald C. Conaway and Jerome Schaack and Aleem Siddiqui},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 20},
  pages={
          10578-83
        }
}
Human hepatitis B virus genome encodes a protein, termed HBx, that is widely recognized as a transcriptional transactivator. While HBx does not directly bind cis-acting transcriptional control elements, it has been shown to associate with cellular proteins that bind DNA. Because HBx transactivated a large number of viral/cellular transcriptional control elements, we looked for its targets within the components of the basal transcriptional machinery. This search led to the identification of its… CONTINUE READING

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